Autoimmunity Is a Significant Feature of Idiopathic Pulmonary Arterial Hypertension

Author:

Jones Rowena J.1ORCID,De Bie Eckart M. D. D.1ORCID,Groves Emily1,Zalewska Kasia I.12,Swietlik Emilia M.12,Treacy Carmen M.1,Martin Jennifer M.1,Polwarth Gary2,Li Wei1,Guo Jingxu1,Baxendale Helen E.2,Coleman Stephen3,Savinykh Natalia4,Coghlan J. Gerry5,Corris Paul A.6,Howard Luke S.7,Johnson Martin K.8,Church Colin8,Kiely David G.9,Lawrie Allan10,Lordan James L.6,Mackenzie Ross Robert V.11,Pepke Zaba Joanna2,Wilkins Martin R.12ORCID,Wort S. John13,Fiorillo Edoardo14,Orrù Valeria14,Cucca Francesco15,Rhodes Christopher J.12,Gräf Stefan1,Morrell Nicholas W.1,McKinney Eoin F.16,Wallace Chris1317ORCID,Toshner Mark12ORCID,Bleda Marta,Hadinnapola Charaka,Haimel Matthias,Auckland Kate,Tilly Tobias,Martin Jennifer M.,Yates Katherine,Treacy Carmen M.,Day Margaret,Greenhalgh Alan,Shipley Debbie,Irvine Val,Kennedy Fiona,Moledina Shahin,MacDonald Lynsay,Tamvaki Eleni,Barnes Anabelle,Cookson Victoria,Chentouf Latifa,Ali Souad,Othman Shokri,Ranganathan Lavanya,Simon J.,Gibbs R.,Gummadi Mahitha,DaCosta Rosa,Pinguel Joy,Dormand Natalie,Parker Alice,Stokes Della,Ghedia Dipa,Tan Yvonne,Ngcozana Tanaka,Wanjiku Ivy,Polwarth Gary,Cannon John,Sheares Karen K.,Taboda Dolores,Mackenzie Ross Rob V.,Suntharalingam Jay,Grover Mark,Kirby Ali,Trembath Richard,

Affiliation:

1. Heart and Lung Research Institute,

2. Royal Papworth Hospital, and

3. Medical Research Council Biostatistics Unit,

4. Cambridge Biomedical Research Centre Phenotyping Hub, Department of Medicine, University of Cambridge,

5. Royal Free London National Health Service Foundation Trust, London, United Kingdom;

6. Freeman Hospital, Newcastle-upon-Tyne, United Kingdom;

7. Hammersmith Hospital, London, United Kingdom;

8. Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, United Kingdom;

9. Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom;

10. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom;

11. Royal United Hospitals Bath National Health Service Foundation Trust, Bath, United Kingdom;

12. National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom;

13. Royal Brompton Hospital, London, United Kingdom;

14. Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy;

15. University of Sassari, Sassari, Italy; and

16. Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom;

17. Department of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, United Kingdom

Funder

National Institute for Health Research (NIHR) Biomedical Research Centre Cambridge, Medical Research Council

Wellcome Trust

Dinosaur Trust

British Heart Foundation

BHF Senior Basic Science Research Fellowship

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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