Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time

Author:

Tang Monica1,Elicker Brett M.2,Henry Travis3,Gierada David S.4,Schiebler Mark L.5,Huang Brendan K.1,Peters Michael C.1,Castro Mario6,Hoffman Eric A.7,Fain Sean B.7,Ash Samuel Y.8,Choi Jiwoong6,Hall Chase6,Phillips Brenda R.9,Mauger David T.10,Denlinger Loren C.11,Jarjour Nizar N.11,Israel Elliot8,Phipatanakul Wanda12,Levy Bruce D.8,Wenzel Sally E.13,Bleecker Eugene R.14,Woodruff Prescott G.115,Fahy John V.115,Dunican Eleanor M.1617

Affiliation:

1. Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine,

2. Department of Radiology and Biomedical Imaging, and

3. Duke Radiology, Department of Radiology, Duke University, Durham, North Carolina;

4. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

5. Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;

6. Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, Kansas City, Kansas;

7. Department of Radiology, University of Iowa, Iowa City, Iowa;

8. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts;

9. Center for Biostatistics and Epidemiology, Pennsylvania State University School of Medicine, Harrisburg, Pennsylvania;

10. Division of Biostatistics and Bioinformatics, Penn State College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania;

11. Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;

12. Asthma, Allergy, Dermatology, Rheumatology, and Immunology, Boston Children’s Hospital, Boston, Massachusetts;

13. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania;

14. Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona;

15. Cardiovascular Research Institute, University of California San Francisco, San Francisco, California;

16. Education and Research Centre, St. Vincent’s University Hospital, Dublin, Ireland; and

17. UCD School of Medicine, University College Dublin, Dublin, Ireland

Funder

National Heart, Lung, and Blood Institute

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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3. Mepolizumab in Patients With Severe Asthma and Comorbidities: 1-Year REALITI-A Analysis;The Journal of Allergy and Clinical Immunology: In Practice;2023-12

4. Eosinophils and tissue remodeling: Relevance to airway disease;Journal of Allergy and Clinical Immunology;2023-10

5. An asthma phenotype comprising bronchial wall thickening and mucus plugging confers worse clinical outcomes;Annals of Allergy, Asthma & Immunology;2023-10

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