Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery

Author:

Douin David J.1,Siegel Lianne2,Grandits Greg2,Phillips Andrew3,Aggarwal Neil R.4,Baker Jason56,Brown Samuel M.78ORCID,Chang Christina C.9,Goodman Anna L.1011,Grund Birgit12,Higgs Elizabeth S.13,Hough Catherine L.14,Murray Daniel D.1516,Paredes Roger1718,Parmar Mahesh19,Pett Sarah19,Polizzotto Mark N.919,Sandkovsky Uriel20,Self Wesley H.2122,Young Barnaby E.232425,Babiker Abdel G.19,Davey Victoria J.26,Kan Virginia27,Gelijns Annetine C.28,Matthews Gail9,Thompson B. Taylor29,Lane H. Clifford13,Neaton James D.2,Lundgren Jens D.1516,Ginde Adit A.30

Affiliation:

1. Department of Anesthesiology,

2. Division of Biostatistics, School of Public Health,

3. Institute for Global Health and

4. Division of Pulmonary Sciences and Critical Care, Department of Medicine, and

5. Department of Medicine, School of Medicine, and

6. Hennepin Healthcare Research Institute, Minneapolis, Minnesota;

7. Division of Pulmonary and Critical Care Medicine, Intermountain Medical Center, Murray, Utah;

8. Department of Internal Medicine, University of Utah, Murray, Utah;

9. The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia;

10. The Medical Research Council Clinical Trials Unit at UCL, University College London, London, United Kingdom;

11. Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom;

12. School of Statistics, University of Minnesota, Minneapolis, Minnesota;

13. National Institute of Allergy and Infectious Diseases, Bethesda, Maryland;

14. Department of Medicine, Oregon Health and Sciences University, Portland, Oregon;

15. CHIP Center of Excellence for Health, Immunity, and Infections, and

16. Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark;

17. Hospital Germans Trias i Pujol, Badalona, Spain;

18. irsiCaixa AIDS Research Institute, Badalona, Spain;

19. John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia;

20. Division of Infectious Diseases, Baylor University Medical Center, Dallas, Texas;

21. Department of Emergency Medicine and

22. Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee;

23. National Centre for Infectious Diseases, Singapore;

24. Tan Tock Seng Hospital, Singapore;

25. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore;

26. United States Department of Veterans Affairs, Washington, DC;

27. Infectious Diseases Section, VA Medical Center, Washington, DC;

28. Department of Population Heath Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York; and

29. Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

30. Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado;

Funder

U.S. Operation Warp Speed Program

National Institute of Allergy and Infectious Diseases

INSIGHT NETWORK

National Heart, Lung, and Blood Institute

Prevention and Early Treatment of Acute Lung Injury (PETAL) Network

Cardiothoracic Surgical Trials Network

Office of Research & Development, U.S. Department of Veterans Affairs

Government of Denmark, National Research Foundation

Australian Government, National Health and Medical Research Council

Government of the United Kingdom, Medical Research Council

National Institutes of Health

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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