Colocalization of Gene Expression and DNA Methylation with Genetic Risk Variants Supports Functional Roles of MUC5B and DSP in Idiopathic Pulmonary Fibrosis

Author:

Borie Raphael1ORCID,Cardwell Jonathan2,Konigsberg Iain R.2ORCID,Moore Camille M.34,Zhang Weiming3,Sasse Sarah K.5,Gally Fabienne26,Dobrinskikh Evgenia27,Walts Avram2,Powers Julie2,Brancato Janna2,Rojas Mauricio8,Wolters Paul J.9,Brown Kevin K.5,Blackwell Timothy S.10,Nakanishi Tomoko11ORCID,Richards J. Brent11ORCID,Gerber Anthony N.256,Fingerlin Tasha E.346,Sachs Norman12,Pulit Sara L.13,Zappala Zachary13,Schwartz David A.214,Yang Ivana V.215

Affiliation:

1. Université Paris Diderot, Paris, France;

2. Department of Medicine,

3. Department of Biostatistics and Bioinformatics and

4. Center for Genes, Environment, and Health,

5. Department of Medicine, and

6. Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado;

7. Department of Pediatrics, and

8. Department of Internal Medicine, Ohio State College of Medicine, The Ohio State University, Columbus, Ohio;

9. Department of Medicine, University of California, San Francisco, California;

10. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;

11. Department of Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Canada;

12. Cell Biology, Vertex Pharmaceuticals, San Diego, California; and

13. Computational Genomics, Vertex Pharmaceuticals, Boston, Massachusetts

14. Department of Microbiology and Immunology, University of Colorado Anschutz Medical Campus; Aurora, Colorado;

15. Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado;

Funder

NIH-National Heart, Lung, and Blood Institute

Vertex Pharmaceuticals

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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