17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma

Author:

Jakwerth Constanze A.1ORCID,Weckmann Markus2,Illi Sabina3,Charles Helen4,Zissler Ulrich M5,Oelsner Madlen6,Guerth Ferdinand4,Omony Jimmy3,Nemani Sai Sneha Priya7,Grychtol Ruth8ORCID,Dittrich Anna-Maria9ORCID,Skevaki Chrysanthi10,Foth Svenja11,Weber Stefanie12,Alejandre Alcazar Miguel A.13,van Koningsbruggen-Rietschel Silke14,Brock Robert14,Blau Samira14,Hansen Gesine1516,Bahmer Thomas171819,Rabe Klaus F.2021,Brinkmann Folke2,Kopp Matthias Volkmar72223,Chaker Adam M.24,Schaub Bianca2521ORCID,von Mutius Erika26,Schmidt-Weber Carsten B.27ORCID,

Affiliation:

1. ZAUM, 621388, Klinikum rechts der Isar der TU München und Helmholtz Zentrum München, Munchen, Germany

2. University Hospital of Schleswig-Holstein, Pediatrics, Lübeck, SH, Germany

3. Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), Institute for Asthma and Allergy Prevention (IAP), Munich, Germany

4. Center of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Zentrum München, Neuherberg and Munich, Germany

5. Technische Universität München, Munich, Germany

6. Klinikum rechts der Isar der Technischen Universitat Munchen, 27190, Center of Allergy and Environment , Munchen, Bayern, Germany

7. Division of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lubeck, Schleswig-Holstein, Germany

8. Hannover Medical School, 9177, Department of Paediatric Pneumology, Allergology and Neonatology , Hannover, Germany

9. Hannover Medical University, Pediatric Pneumology, Allergology and Neonatology, Hannover, Germany

10. Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg and University of Gießen, Marburg, Hessen, Germany

11. University of Marburg, University of Giessen and Marburg Lung Center (UHMLC), Marburg, Hessen, Germany

12. University Hospital Marburg, Dept. of Pediatrics, Marburg, Hessen, Germany

13. University of Marburg, 9377, Institute for Lung Health (IHL), Marburg, Hessen, Germany

14. University of Cologne, 14309, Pediatric Pulmonology and Allergology, Department of Pediatrics, Koln, Nordrhein-Westfalen, Germany

15. Hannover Medical School, Pediatric Pulmonology, Allergology and Neonatology, Hannover, Germany

16. German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover, Germany

17. University Hospital Schleswig-Holstein - Campus Kiel, 54186, Internal Medicine Department I, Pneumology, Kiel, Schleswig-Holstein, Germany

18. LungenClinic Grosshansdorf GmbH, 9213, Grosshansdorf, Schleswig-Holstein, Germany

19. Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany

20. University Kiel & LungenClinic, Grosshansdorf, Germany

21. Germany

22. Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Lubeck, Germany

23. Department of Pediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland

24. Technical University of Munich Hospital Rechts der Isar, 27190, Otorhinolaryngology / Head and Neck Surgery, Munich, Bayern, Germany

25. Univerity Childrens Hospital, Pulmonary & Allergy, Munich, Germany

26. University Children's Hospital, Munich, Germany

27. Center of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Zentrum München, Neuherberg and Munich, Germany;

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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