Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis

Author:

Lee Mikyeong1ORCID,Huan Tianxiao23,McCartney Daniel L.4ORCID,Chittoor Geetha56ORCID,de Vries Maaike78ORCID,Lahousse Lies910ORCID,Nguyen Jennifer N.11,Brody Jennifer A.12ORCID,Castillo-Fernandez Juan13ORCID,Terzikhan Natalie10,Qi Cancan814,Joehanes Roby3ORCID,Min Josine L.1516ORCID,Smilnak Gordon J.1,Shaw Jessica R.17ORCID,Yang Chen Xi18ORCID,Colicino Elena19,Hoang Thanh T.1ORCID,Bermingham Mairead L.4ORCID,Xu Hanfei20,Justice Anne E.56,Xu Cheng-Jian21222324ORCID,Rich Stephen S.11ORCID,Cox Simon R.25ORCID,Vonk Judith M.78,Prokić Ivana10ORCID,Sotoodehnia Nona26,Tsai Pei-Chien132728ORCID,Schwartz Joel D.293031ORCID,Leung Janice M.18,Sikdar Sinjini132ORCID,Walker Rosie M.4,Harris Sarah E.25ORCID,van der Plaat Diana A.733ORCID,Van Den Berg David J.3435ORCID,Bartz Traci M.36,Spector Tim D.13,Vokonas Pantel S.37,Marioni Riccardo E.4ORCID,Taylor Adele M.25,Liu Yongmei38ORCID,Barr R. Graham3940,Lange Leslie A.1741ORCID,Baccarelli Andrea A.42,Obeidat Ma’en43ORCID,Fornage Myriam4445,Wang Tianyuan46ORCID,Ward James M.46,Motsinger-Reif Alison A.47ORCID,Hemani Gibran1516ORCID,Koppelman Gerard H.814ORCID,Bell Jordana T.13ORCID,Gharib Sina A.1248ORCID,Brusselle Guy104950,Boezen H. Marike78,North Kari E.6ORCID,Levy Daniel3,Evans Kathryn L.4ORCID,Dupuis Josée20ORCID,Breeze Charles E.51ORCID,Manichaikul Ani11ORCID,London Stephanie J.1ORCID

Affiliation:

1. Epidemiology Branch,

2. Department of Ophthalmology, University of Massachusetts Medical School, Worcester, Massachusetts;

3. Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, Framingham, Massachusetts;

4. Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer and

5. Department of Population Health Sciences, Geisinger, Danville, Pennsylvania;

6. Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina;

7. Department of Epidemiology,

8. Groningen Research Institute for Asthma and COPD, and

9. Department of Bioanalysis, Ghent University, Ghent, Belgium;

10. Department of Epidemiology and

11. Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia;

12. Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine,

13. Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom;

14. Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

15. Medical Research Council Integrative Epidemiology Unit and

16. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom;

17. Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, and

18. Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;

19. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York;

20. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts;

21. Centre for Individualised Infection Medicine, a joint venture between Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany;

22. Research Group Bioinformatics and Computational Genomics, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany;

23. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany;

24. Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands;

25. Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom;

26. Cardiovascular Health Research Unit, Division of Cardiology, Department of Epidemiology,

27. Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan;

28. Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan;

29. Department of Environmental Health and

30. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts;

31. Channing Laboratory, Harvard Medical School, Boston, Massachusetts;

32. Department of Mathematics and Statistics, Old Dominion University, Norfolk, Virginia;

33. National Heart and Lung Institute, Imperial College London, London, United Kingdom;

34. Department of Preventive Medicine and

35. Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California;

36. Cardiovascular Health Research Unit, Department of Biostatistics,

37. Veterans Affairs Boston Healthcare System, School of Medicine and School of Public Health, Boston University, Boston, Massachusetts;

38. Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina;

39. Department of Medicine and

40. Department of Epidemiology, Columbia University Medical Center, New York, New York;

41. Department of Epidemiology, University of Colorado, Aurora, Colorado;

42. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York;

43. Centre for Heart Lung Innovation, The University of British Columbia, St. Paul’s Hospital, Vancouver, British Columbia, Canada;

44. Brown Foundation Institute of Molecular Medicine, McGovern Medical School, and

45. Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, Texas;

46. Integrative Bioinformatics Support Group, and

47. Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina;

48. Computational Medicine Core, Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington;

49. Department of Respiratory Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands;

50. Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; and

51. Altius Institute for Biomedical Sciences, Seattle, Washington

Funder

National Institutes of Health

National Institute of Environmental Health Sciences

National Heart, Lung, and Blood Institute

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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