A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality

Author:

Verma Anurag12,Minnier Jessica345,Wan Emily S.67,Huffman Jennifer E.8,Gao Lina45,Joseph Jacob910,Ho Yuk-Lam8,Wu Wen-Chih1112,Cho Kelly813,Gorman Bryan R.8,Rajeevan Nallakkandi1415,Pyarajan Saiju816,Garcon Helene8,Meigs James B.17,Sun Yan V.1819,Reaven Peter D.2021,McGeary John E.2223,Suzuki Ayako2425,Gelernter Joel2627,Lynch Julie A.2829,Petersen Jeffrey M.130,Zekavat Seyedeh Maryam3132,Natarajan Pradeep163332,Dalal Sharvari130,Jhala Darshana N.130,Arjomandi Mehrdad34ORCID,Gatsby Elise28,Lynch Kristine E.2835,Bonomo Robert A.29,Freiberg Matthew9,Pathak Gita A.2627,Zhou Jin J.3637,Donskey Curtis J.38,Madduri Ravi K.39,Wells Quinn S.94041,Huang Rose D. L.8,Polimanti Renato2627,Chang Kyong-Mi1,Liao Katherine P.42,Tsao Philip S.43,Wilson Peter W. F.4419,Hung Adriana M.45,O’Donnell Christopher J.46,Gaziano John M.8,Hauger Richard L.4748,Iyengar Sudha K.4950,Luoh Shiuh-Wen45,

Affiliation:

1. Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania;

2. Department of Medicine, Perelman School of Medicine, and

3. OHSU-PSU School of Public Health and

4. Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon;

5. VA Portland Health Care System, Portland, Oregon;

6. Department of Medicine, Pulmonary, Critical Care, Sleep, and Allergy Section,

7. Channing Division of Network Medicine and

8. MAVERIC,

9. Department of Medicine,

10. Medicine, Cardiovascular, Brigham & Women’s Hospital, Boston, Massachusetts;

11. Department of Medicine, Cardiology, Providence VA Healthcare System, Providence, Rhode Island;

12. Alpert Medical School & School of Public Health, Brown University, Providence, Rhode Island;

13. Medicine, Aging, Brigham & Women’s Hospital and

14. Yale Center for Medical Informatics,

15. Clinical Epidemiology Research Center (CERC),

16. Department of Medicine, Harvard Medical School, Boston, Massachusetts;

17. Medicine, General Internal Medicine and

18. Epidemiology, School of Public Health and

19. Atlanta VA Healthcare System, Decatur, Georgia;

20. Department of Medicine, Phoenix VA Healthcare System, Phoenix, Arizona;

21. College of Medicine, University of Arizona, Phoenix, Arizona;

22. Department of Psychiatry and Human Behavior, Providence VA Medical Center, Providence, Rhode Island;

23. Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, Rhode Island;

24. Department of Medicine, Gastroenterology, Durham VA Medical Center, Durham, North Carolina;

25. Department of Medicine, Gastroenterology, Duke University, Durham, North Carolina;

26. Division of Human Genetics, Department of Psychiatry, and

27. VA Connecticut Healthcare System, West Haven, Connecticut;

28. VA Informatics & Computing Infrastructure (VINCI), VA Salt Lake City Healthcare System, Salt Lake City, Utah;

29. Department of Medicine and

30. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

31. Computational Biology & Bioinformatics, Yale University School of Medicine, New Haven, Connecticut;

32. Program in Medical and Population Genetics, Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts;

33. Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts;

34. Medicine, Pulmonary and Critical Care, San Francisco VA Healthcare System, University of California, San Francisco, San Francisco, California;

35. Internal Medicine, Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah;

36. Department of Medicine, University of California, Los Angeles, Los Angeles, California;

37. Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona;

38. Infectious Disease Section and

39. Data Science and Learning, Argonne National Laboratory, Lemont, Illinois;

40. Department of Biomedical Informatics, and

41. Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee;

42. Medicine, Rheumatology, and

43. Precision Medicine, VA Palo Alto Health Care System, Palo Alto, California;

44. Emory University, Atlanta, Georgia;

45. Department of Veteran’s Affairs, Tennessee Valley Healthcare System, Vanderbilt University Medical Center, Division of Nephrology & Hypertension, Nashville, Tennessee;

46. Medicine, Cardiology, VA Boston Healthcare System, Boston, Massachusetts;

47. Center of Excellence for Stress & Mental Health, VA San Diego Healthcare System, San Diego, California; and

48. Center for Behavioral Genetics of Aging, University of California, San Diego, La Jolla, California

49. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio;

50. Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio;

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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