Targeting uPAR in diabetic vascular pathologies*-Reference-Cited by-同舟云学术

Targeting uPAR in diabetic vascular pathologies*

Published:2019-12-31 Issue: Volume:73 Page:803-808
ISSN:0032-5449
Container-title:Postępy Higieny i Medycyny Doświadczalnej
language:
Short-container-title:Postepy Hig Med Dosw

Author:

Durak-Kozica Martyna¹,Enguita Francisco J.²,Stępień Ewa¹

Affiliation:

1. Department of Medical Physics, M. Smoluchowski Institute of Physics, Jagiellonian University, Kraków, Poland

2. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

Abstract

The uPAR protein is one of the most important elements in fibrinolysis. uPAR is associated with many biological processes, such as cell invasion, angiogenesis and cell proliferation. Because of its multifunctional character, it is difficult to produce an effective inhibitor of uPA-uPAR interactions. The present paper shows the current state of knowledge about the contribution of uPA-uPAR complex in many biological processes and the application of uPAR inhibitors (antibodies, small-molecules, peptides), which might be potentially useful in the treatment of vascular pathologies.

Publisher

Walter de Gruyter GmbH

Subject

Infectious Diseases,Microbiology (medical)

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