[1,2,4]triazines – as potential drugs in cancer chemotherapy

Abstract

Cancers are a high risk for humanity. In 2018, approximately 18 million new cancer cases were diagnosed in the world. The choice of treatment depends on the type of cancer and its stage at diagnosis. The treatment of cancer consists mainly of surgical methods, radiotherapy, immunotherapy, hormone therapy and chemotherapy. Cytotoxic drugs can be used both in monotherapy and combination therapy. In 2009-2018, the US. Food and Drug Administration (FDA) approved about 356 new drugs for cancer therapy. However, it should be noted that despite the increasing availability of modern drugs, this disease is the second leading cause of death in the world. Research on the development of a cytotoxic drug is aimed at designing a compound structure, whose action is directed at cancer cells while not affecting normal cells. Triazine derivatives might be the chemical structure with potential anticancer activity. This scaffold has been used in oncological therapy since 1965. Depending on the location of the nitrogen atoms in the ring, three isomers can be distinguished: [1,2,3]triazines, [1,2,4]triazines, [1,3,5]triazines. Modification of the structure of the [1,2,4]triazine derivatives should provide stronger cytotoxic properties and reduce the side effects of the novel drug. Designing new preparations also aims to improve the patient’s quality of life. This review will briefly present how the modification of the chemical structure of [1,2,4]triazine derivatives increases their cytotoxic activity against cancer and why these compounds may be better tolerated than current therapy.