Fecal microbiota transplantation as a possibility of curing Irritable Bowel Syndrome FMT as a possibility of curing IBS

Abstract

Introduction and Objective. Irritable Bowel Syndrome (IBS) became recently a common problem among the population of highly developed countries. Most patients suffer from chronic abdominal pain and various bowel habit disorders. Although the pathogenesis of IBS was not yet entirely defined, intestinal dysbiosis is frequently mentioned as one of the most possible mechanisms. There may be a way to permanently cure IBS, by replacing patient’s dysbiotic intestinal microflora with a Fecal Microbiota Transplantation (FMT) from a healthy donor. The purpose of this paper is to present FMT as a method of IBS treatment.Review methods. Search using PubMed database using the combined keywords: "Irritable Bowel Syndrome", "Fecal Microbiota Transplantation", "Dysbiosis" "Intestinal Microbiota". An attempt was made to present a comprehensive state of knowledge while indicating areas that require further research. Brief description of the state of knowledge. Effectiveness of FMT in IBS has been clinically proven and seems to be donor-dependent. Superdonor’s microbiota profile has not been defined yet. FMT is gradually gaining popularity as new research appears confirming long-term effectiveness of the procedure.Summary. Research results are promising and it seems likely that FMT will be introduced as a treatment method routinely used in clinical practice. Differences in test results may be related to the use of material from various donors. It is important to establish the exact dosage, frequency of the procedure, criteria for selecting superdonors, and if material from more than one donor should be used, among other things.