Withania somnifera a journey from traditionalrejuvenator to anti-SARS-CoV-2 remedy-Reference-Cited by-同舟云学术

Withania somnifera a journey from traditionalrejuvenator to anti-SARS-CoV-2 remedy

Published:2023-05-30 Issue:2 Volume:69 Page:37-51
ISSN:0018-0599
Container-title:Herba Polonica
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Author:

ASHOKKUMAR KALIYAPERUMAL¹,PANDIAN ARJUN²,BASKAR MOHAN³,KARTHIK MANIKAM⁴,MURUGAN MUTHUSAMY⁵,BADONI SEMWAL RUCHI⁶,KUMAR SEMWAL DEEPAK⁷

Affiliation:

1. 1 Cardamom Research Station Kerala Agricultural University Pampadumpara, Idukki – 685553, Kerala, India

2. Department of Research and Innovation, Institute of Biotechnology Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences Thandalam, Chennai 602105, Tamil Nadu, India

3. Department of Botany Government Arts College for Men (Autonomous) Nandanam, Chennai 600035, Tamil Nadu, India

4. Department of Agricultural Microbiology Tamil Nadu Agricultural University Coimbatore, Tamil Nadu, India

5. Cardamom Research Station Kerala Agricultural University Pampadumpara, Idukki – 685553, Kerala, India

6. Department of Chemistry VSKC Government Postgraduate College Dakpathar, Dehradun, Uttarakhand, India

7. Department of Phytochemistry, Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala, Dehradun, India

Abstract

Ashwagandha (Withania somnifera L. Dunal) roots have been used in Ayurveda for fever, asthma, arthritis,rheumatism, inflammation, tuberculosis, mental diseases, and male sexual disorders. Phytochemical studiesrevealed that the plant mainly contains alkaloids (withanine, sominiferine, tropine, isopelletierine andanaferine), and steroidal lactones (withanolides A-Y, withaferine A, withasominiferols A-C, withanone and sitoindosides) as bioactive metabolites. These constituents and extracts have several pharmacologicalactivities, including antioxidant, antitumour, antimicrobial, antivenom, and anti-parkinsonian activities.The present review presents updated information on ashwagandha based on its phytochemistry andpharmacology. The plant and many of its secondary metabolites have been found to be effective in thetreatment of many human ailments. However, further investigations are still needed to understand the exactmechanism of their actions.

Publisher

Index Copernicus

Subject

Complementary and alternative medicine,Plant Science,Pharmacology,Ecology, Evolution, Behavior and Systematics

Reference109 articles.

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