The assessment of phagocytic and bactericidal activity of platelets and plasma bactericidal activity in late preterm newborns

Author:

Wasiluk Alicja1,Kicel-Wesolowska Barbara2,Milewski Robert3,Matowicka-Karna Joanna4

Affiliation:

1. Department of Neonatology Medical University of Bialystok, Bialystok, Poland

2. Department of Gynecology and Obstetrics, District Hospital in Bialystok, Bialystok, Poland

3. Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland

4. Department of Clinical Laboratory Diagnostics Medical University of Bialystok, Bialystok, Poland

Abstract

Background: The aim of the study was to compare the phagocytic and bactericidal properties of blood platelets and the plasma bactericidal activity in 66 late preterm (LPN) and 74 full-term newborns (FTN). Materials/Methods: Blood samples were collected from the umbilical artery. Bacteria of the Staphylococcus aureus ATCC 6538P were used for the tests. Results: Platelet counts in LPN vs FTN were the following: 225 vs 258.5 (x10³/μL), p = 0.003. The percentage of phagocytic platelets was the following: Me = 1.1 in LTN vs Me = 1.1 in FTN. The phagocytic index was the following: Me = 1 for both LPN and FTN. The phagocytic properties of platelets increased as the birth weight increased. The bactericidal activity of platelets was the following: Me = 0; (average = 0.7) in LPN vs Me = 0; (average = 0.8) in FTN. The median plasma bactericidal activity in LPN was 41.6 vs 43.8, in FTN, p = 0.027. The bactericidal capacity of plasma increased with increasing fetal age and birth weight of newborns. sP-selectin was: 63.9 ng/ml in LPN vs 71 ng/ml in FTN, p = 0.026. IL-6 in LPN was 3.6 vs 3.9 (pg/ml) in FTN, p = 0.02. Conclusion: Late preterm newborns have lower defensive capacity against infection than full-term newborns, due to lower platelets count, lower plasma bactericidal activity and lower sP-selectin concentration, which cooperates with neutrophils, monocytes in fighting against infection. All newborns had similar phagocytic and bactericidal properties of platelets.

Publisher

Walter de Gruyter GmbH

Subject

Infectious Diseases,Microbiology (medical)

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