Serum uromodulin as a marker of kidney graft function*-Reference-Cited by-同舟云学术

Serum uromodulin as a marker of kidney graft function*

Published:2019-01-07 Issue: Volume:73 Page:729-734
ISSN:0032-5449
Container-title:Postępy Higieny i Medycyny Doświadczalnej
language:
Short-container-title:Postepy Hig Med Dosw

Author:

Nowosiad-Magda Monika¹,Roszkowska Paulina¹,Myślak Marek²,Wojciechowska-Koszko Iwona¹,Domański Leszek²,Rożański Jacek²,Marchelek-Myśliwiec Małgorzata²,Ciechanowski Kazimierz²,Dołęgowska Barbara¹

Affiliation:

1. Department of Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, Szczecin, Poland

2. Department of Nephrology, Transplantology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland

Abstract

Serum uromodulin (sURO) was recently found as a sensitive tubular marker in early chronic kidney disease stages. Thus far, mainly early uromodulin urinary excretion was tested in kidney recipients. The aim of our study was to conduct a long-lastinlong-term assessment of sURO in kidney graft function monitoring. Forty-one stable kidney recipients (aged 47 (13.7)) were studied around the 3<sup>rd</sup> month (3m) and the 2<sup>nd</sup> year (2y) after kidney transplantation. Sera were tested for sURO, creatinine and tacrolimus levels. Kidney biopsy was scored according to revised Banff 97 classification. sURO level (mean 66.06ng/ml at 3m; 77.81 at 2y) increased borderline significantly (P = 0.051) in time and significantly correlated with eGFR (3m RS = 0.46; 2y RS = 0.58), creatinine levels (RS respectively –0.55 and –0.56) and donor age (3m Rs = –0.33; 2y RS = –0.41). We observed borderline correlations between sURO and Banff biopsy scoring: 3m-sURO with arteriolar hyalinosis-ah (RS = –0.3, P = 0.06) and 2y-sURO with peritubular capillaritis-ptc (RS = 0.45, P = 0.07). Correlations of sURO with 3m tacrolimus levels (Rs = 0.3, P = 0.08) were borderline, however patients with CNI toxicity lesions in biopsy had sURO significantly lower (mean 3m-sURO 52.7 vs 83.1 ng/ml; 2y-sURO 61.9 vs 98.1 ng/ml). sURO can reflect kidney graft quality and function. sURO correlated with ptc, which is considered to be an early marker of a chronic antibody-mediated graft injury. Tacrolimus doesn’t influence sURO levels directly, but sURO is lower in patients with toxic kidney injury in biopsy.

Publisher

Walter de Gruyter GmbH

Subject

Infectious Diseases,Microbiology (medical)

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