Prognostic value of using neutrophil-lymphocyte ratio in patients with burn injury for the diagnosis of sepsis and bacteraemia

Abstract

Objective. At present time, despite the progress made in the treatment of burn injuries, mortality rate among seriously ill patients remains high. The main causes of fatal cases with the extensive deep burns are generalized infectious complications, the major of which is sepsis. According to the authors, from 25 to 85% of deceased in later periods of burn injuries die from sepsis. The frequency and severity of infectious complications in patients with burn injuries requires an accurate diagnosis of infection that will determine the tactics of therapeutic and surgical treatment of such patients (Di Lonardo A. et al., 1993). However, the clinical diagnosis of wound infection in patients with burn injuries is quite difficult. Materials and methods. Clinical material makes 188 patients with burn injuries. The average age of patients ranged from 20 to 59 years. Men  98 (52.1%), women  90 (47.9%). The survey has been conducted from April 2014 to July 2016. Results. In our opinion, the strength of the NLR (neutrophil-lymphocyte ratio) is the possibility of implementing this parameter simply by using already available biomarkers (neutrophil count and lymphocyte count). Therefore, this ratio is easy to integrate in clinical practice and cost effective. Conclusion. The application of NLR for the diagnosis of sepsis in patients with burn injuries is the option of choice, since its determination requires only the overall blood test.