Design and synthesis of new anilide and benzylamide derivatives as potential multifunctional ligands with procognitive and antidepressant activity-Reference-Cited by-同舟云学术

Design and synthesis of new anilide and benzylamide derivatives as potential multifunctional ligands with procognitive and antidepressant activity

Published:2022-02-24 Issue: Volume:9 Page:1-8
ISSN:2082-8470
Container-title:Postępy Polskiej Medycyny i Farmacji
language:
Short-container-title:Post Pol Med Farm

Author:

Jankowska Agnieszka¹,Chłoń-Rzepa Grażyna¹

Affiliation:

1. Zakład Chemii Leków, Katedra Chemii Farmaceutycznej, Wydział Farmaceutyczny, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Polska

Abstract

The search for new drugs in the treatment of cognitive and mood disorders belongs to the leading research directions due to the growing prevalence of dementia and depression. The limited therapeutic efficacy of substances with a selective mechanism of action prompts the design of drugs among multifunctional ligands, i.e., molecules with a complex mechanism of action. This paper is an overview of the current research in the field of design and synthesis of potential multifunctional ligands with CNS activity. The serotonin 5-HT1A/5-HT7 receptor ligands and phosphodiesterase PDE4B/PDE7A inhibitors were shown to have procognitive and antidepressant properties in vivo. They may provide higher efficacy in the treatment of cognitive and depressive symptoms of neurodegenerative and mental disorders.

Publisher

Index Copernicus

Subject

Psychiatry and Mental health

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