Weaning from high-dose opioids (fentanyl and oxycodone) two case reports

Author:

Kurek Michał1,Kurek Izabela2,Zaorska Justyna3,Fiszer Urszula4,Malec-Milewska Małgorzata5

Affiliation:

1. Wydział Medyczny, Uczelnia Łazarskiego w Warszawie; Kliniczny Oddział Psychiatryczny Mazowieckiego Szpitala i Centrum Diagnostycznego MindHealth, Warszawa, Polsk

2. II Klinika Anestezjologii i Intensywnej Terapii, Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego, Warszawa, Polska

3. Katedra i Klinika Psychiatryczna, Warszawski Uniwersytet Medyczny, Warszawa, Polska

4. Klinika Neurologii i Epileptologii, CMKP, Warszawa, Polska

5. Poradnia Leczenia Bólu, Klinika Anestezjologii i Intensywnej Terapii, CMKP, Warszawa, Polska

Abstract

We present two cases of weaning from high-dose opioids (fentanyl and oxycodone. The first case concerns a 26-year-old patient with mitochondrial syndrome and neuropathic pain in the lower limbs, addicted to high doses of transdermaland transmucosal fentanyl (transdermal fentanyl 150 g/h in the form of patches every 3 days and transmucosalfentanyl 300 g/dose applied intranasally every 1 hour). The second case concerns a 32-year-old patient with chronicpost-traumatic pain and post-traumatic stress disorder, addicted to a high dose of oxycodone (1600 mg/day).Unfortunately, only in the first case, the desired effect was achieved discontinuation of fentanyl and remission of pain.In the second case, the patient resigned from further treatment in the pain management clinic despite achieving theintended therapeutic effect switching oxycodone to buprenorphine and reducing pain intensity

Publisher

Index Copernicus

Subject

General Medicine

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