The influence of pyrethroides: permethrin, deltamethrin and alpha-cypermetrin on oxidative damage

Abstract

Pyrethroids, synthetic derivatives of natural pyrethrins derived from Chrysanthemum cinerariaefolim, are commonly used for plant protection in the forestry, agricultural, pharmaceutical industry as well as in medicine and veterinary medicine. They can enter the body by inhalation, ingestion and skin contact. It was assumed that they are characterized by low toxicity to humans, are quickly metabolized and do not accumulate in tissues, and are excreted in the urine. Despite the existing restrictions, their use carries a great risk, because these compounds and their metabolites can get into the natural environment, contaminating water, soil and food. The consequences of using pyrethroids as a direct threat to animal and human health have been described for many years. They are published on an ongoing basis informing about poisoning with these compounds in humans and animals, and about fatalities after their taking. Children are most at risk because pyrethroids can be found in breast milk. These compounds have nephrotoxic, hepatotoxic, immunotoxic, neurotoxic effects and have a negative effect on the reproductive system and the fetus. Pyrethroids such as permethrin, deltamethrin, alpha-cypermethrin are approved by the World Health Organization for daily use; however, numerous scientific studies indicate that they can cause oxidative stress. They lead to DNA, protein, lipid damage and induction of apoptosis. The purpose of the work was to collect and systematize the available knowledge regarding the induction of oxidative stress by selected pyrethroids.