Application of an ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model – a proof of concept-Reference-Cited by-同舟云学术

Application of an ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model – a proof of concept

Published:2023-12-31 Issue:1 Volume:19 Page:31-34
ISSN:1896-530X
Container-title:Bio-Algorithms and Med-Systems
language:
Short-container-title:Bio-Algorithms and Med-Systems

Author:

Durak-Kozica Martyna¹^ORCID,Stępień Ewa¹^ORCID,Swakoń Jan²^ORCID,Moskal Paweł¹^ORCID

Affiliation:

1. Marian Smoluchowski Institute of Physics, Jagiellonian University; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University; Centre for Theranostics, Jagiellonian University, Krakow, Poland

2. Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland

Abstract

Ultra-high dose rate (FLASH) proton radiotherapy is a promising treatment method for cancer patients. In our research, we want to compare the FLASH method with a conventional radiation method to show what effect they have on the biochemical structure of the tumour (3D model – spheroids) and the secretion of extracellular vesicles (EVs) and their cargo. The use of a modern method of creating spheroids will enable us to create conditions that are better able to mimic the tumour microenvironment.

Publisher

Index Copernicus

Link

https://bamsjournal.com/gicid/pdf/01.3001.0054.1820

Reference36 articles.

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