Revision of diagnostic guidelines for parathyroid adenoma based on case reports and a literature review

Author:

Zabielska Bernadeta1,Rzepakowska Anna2

Affiliation:

1. Student Scientific Research Group at the Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland

2. Department of Otorhinolaryngology, Head and Neck Surgery at the Medical University of Warsaw, Poland

Abstract

<b>Introduction:</b> Parathyroid adenoma is a benign tumor that affects the parathyroid glands, small organs in the neck that produce parathyroid hormone (PTH). The most common cause of adenoma is a mutation in the MEN1 gene. When a person has a parathyroid adenoma, the affected gland produces excess PTH, which can lead to high levels of calcium in the blood (hypercalcemia). Symptoms of hypercalcemia can include fatigue, weakness, bone pain, kidney stones, excessive thirst, and urination. Diagnosis of parathyroid adenoma typically involves blood tests to measure calcium and PTH levels, as well as imaging tests such as ultrasound, CT, or MRI to locate the tumor. Treatment most often involves surgical removal of the adenoma, which effectively cures the hypercalcemia in most cases. </br></br> <b>Case reports:</b> The article presents two cases of patients with parathyroid adenoma, concentrating on the symptomatology, diagnostic workup, and treatment. We searched for and verified the recommendations in the recent literature to revise the diagnostic guidelines for this pathology.

Publisher

Index Copernicus

Subject

Otorhinolaryngology

Reference8 articles.

1. Madkhali T., Alhefdhi A., Chen H., Elfenbein D.: Primary hyperparathyroidism.Ulus Cerrahi Derg., 2016; 32(1): 58–66.

2. AACE/AAES Task Force on Primary Hyperparathyroidism: The AmericanAssociation of Clinical Endocrinologists and the American Association ofEndocrine Surgeons position statement on the diagnosis and management ofprimary hyperparathyroidism. Endocr. Pract., 2005; 11(1): 49–54.

3. Garas G., Poulasouchidou M., Dimoulas A., Hytiroglou P., Kita M. et al.: Radiologicalconsiderations and surgical planning in the treatment of giant parathyroidadenomas. Ann R Coll Surg Engl., 2015; 97(4): e64–66.

4. Neagoe R.M., Sala D.T., Borda A., Mogoanta C.A., Muhlfay G.: Clinicopathologicand therapeutic aspects of giant parathyroid adenomas - three case reports and shortreview of the literature. Romanian J Morphol Embryol., 2014; 55(2 Suppl): 669–674.

5. Fuhrman G.M., Bolton J.S.: Department of Surgery, Ochsner Clinic and AltonOchsner Medical Foundation, New Orleans, LA. Minimally Invasive ParathyroidSurgery. Ochsner J., 2000; 2: 168–171.

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