Biomarkers of myocardial injury in big laboratory data

Abstract

<br><b>Introduction:</b> In one of the research projects implemented under the National HealthProgramme, an analysis of the so-called “real world data” (RWD) was performed, regardingthe use of cardiac troponins carried out in the years 2014-2019 in the laboratories of one of the leading network diagnostic companies. The cardiac troponins T and I (cTnT and cTnI), including high-sensitivity cTnI (hs cTnI) were analyzed.</br><br><b>Aim:</b> The aim of the study was to evaluate usability of routinely collected data from laboratorytest to assess the health status of the population.</br><br><b>Results:</b> The results of the analysis showed a systematic growth of number of tests; in 2018(the last full year of observation) it was 216,000: from which cTnT tests accounted for about70%, cTnI and hs cTnI accounted for about 30%. At that time, there was a clear technologicalshift in troponin I research towards highly sensitive hs cTnI tests (27% in 2019). Due to thequality and recording of data, the results of the tests could only be analyzed in the caseof troponin T. In this category, approximately 60% revealed incorrect results; in the case ofwomen, this percentage was lower and amounted to 55% on average, and 65% for men.</br><br><b>Conclusions:</b> Observations made during the analysis indicate the need for greaterstandardization of information on laboratory tests, especially in the context of the introductionof Electronic Medical Records (EDM) and recent initiatives of Digital Medicine Centres.</br>