Role of non-collagenous proteins in dentinee formation and mineralization. Part I. SLRP proteoglycans in dentineogenesis

Abstract

An early stage of dentine formation and its later appropriate mineralization require the deposition of collagen type I and subsequent deposition of multiple non-collagenous proteins. The most critical non-collagenous proteins for dentineogenesis belong to two families, the Small Leucine Rich Proteoglycans (SLRP) and the Small Integrin-Binding Ligands (SIBLING). The threepart manuscript summarizes current knowledge of the molecular mechanism of dentineogenesis. It argues the confirmed but also speculative theses about the function of non-collagenous proteins and their potential role in the formation of sclerotic dentine. In the opinion of the authors this may play a key role in the planning of prosthetic treatment. Considering the current knowledge of dentine a number of opponents speculate that long-lasting teeth grinding and clenching might modify the level of expression of the non-collagenous proteins in dentine, and thus invalidate or impair further prosthetic treatment. The first part of the manuscript contains a short introduction to dentine formation and roles of the SLRP family proteoglycans in the process of�dentineogenesis. The emphasis has been put on two proteoglycans: decorin and biglycan and their ability to interfere with the process of spatial orientation of the collagenous fibres in dentine.