Affiliation:
1. Department of Hospital Therapy named after Academician G.I. Storozhakov Medical Faculty N.I. Pirogov Russian national research medical university
2. Department of Hospital Therapy named after Academician G.I. Storozhakov Medical Faculty N.I. Pirogov Russian national research medical university; Federal state autonomous scientific institution «Chumakov Federal scientific center for research and development of immune-and- biological products of Russian academy of sciences» (Institute of poliomyelitis)
3. Department of Hospital Therapy named after Academician G.I. Storozhakov Medical Faculty N.I. Pirogov Russian national research medical university; State Clinical hospital named after V.M. Buyanov
Abstract
Patients with chronic liver diseases (CLD) are at high risk of infection and severe COVID-19 (Corona Virus Disease).Aim: to create a database of patients with CLD, including an analysis of the frequency of detection of SARS-CoV-2 markers, the causes of hospitalization, an assessment of 30-day mortality in the presence of COVID-19 markers and in the absence of infection.Materials and methods. A one-time retrospective observational comparative study was conducted, the result of which was the creation of a database. 693 electronic case hystories of patients with CLD of various etiologies hospitalized in the V.M. Buyanov State Clinical Hospital for the period 01.04.2020–01.10.2021 were analyzed. Th e analysis included the following parameters: gender, age, etiology of the disease, reasons for hospitalization, the presence of ribonucleic acid (RNA) SARS-CoV-2 in a smear of the nasal mucosa and oropharynx, antibodies to SARS-CoV-2 immunoglobulins of classes M, G (IgM, IgG), the outcome of the disease (30-day mortality).Results. Markers of past new coronavirus infection (IgG) were detected in 268 (38,7 %), SARS-CoV-2 RNA was detected in 67 (9,7 %). Th e analysis of the causes of hospitalization revealed the predominance of edematous ascitic syndrome (64,5 %), an increase in hepatic encephalopathy (31,6 %) and an increase in the number of cases of portal vein thrombosis (PVT) (8,9 %). When assessing the 30-day mortality, signifi cant diff erences were found in patients with Alcohol-related liver disease (ARLD), chronic viral hepatitis in the presence of COVID-19 markers and in cases of their absence.Conclusion. SARSCoV-2 markers were found in 335 (48,3 %) of patients with CLD. Th e main reason for hospitalization is the appearance /increase of edematous ascitic syndrome, including due to PVT. 30-day mortality in the postcovid period is signifi cantly higher (р = 0,0246) in ARLD compared with patients without COVID-19 (218 (34,9 %) и 300 (25,3 %), respectively, р = 0,0246).