The Research of General Reaction: Synthesis of Erythromycin Derivatives Impurities about N-demonomethyl Compounds

Abstract

Abstract Erythromycin derivatives have been used as antibacterial drugs in clinic for many years. As lacking of relevant impurities, those drugs quality control are limited. So, we carried out a research of general reaction: synthesis of 3 “- N-demonomethyl - Erythromycin, 3 “- N-demonomethyl - Clarithromycin, 3 “- N- demonomethyl - Roxithromycin and 3 “- N-demonomethyl- Azithromycin by using Erythromycin, Clarithromycin, Roxithromycin and Azithromycin as the raw material respectively. Using 1HNMR, 13CNMR and MS identified those impurities structures. Our methods have many advantages: raw materials cheap, getting easily, safely and stability, high yield and good purity, and it also can use for quality control of Erythromycin derivatives and new drug development based on 3“-N-demonomenthyl macrolide compounds.