Iron oxide nanoparticles mediated hyperthermia on cancer cell lines

Abstract

Abstract Nanotechnology is the engineering of functional systems at the molecular scale. The technology can be used to treat cancer by the application of hyperthermia to magnetic nanoparticles and is found to be effective in cancer repression. Iron oxide nanoparticles were synthesized by co-precipitation method. Synthesized nanoparticles were ranging from 10 to 20nm size with Iron concentration of 6 μg. Cancer cell lines, A549 and HeLa, were subjected to hyperthermia treatment and the effect of iron oxide nanoparticles was analysed by Microscopic and Spectroscopic analysis, along with MTT assay in order to check the toxicity of the nanoparticles. Viability of the cells with respect to the concentration of the nanoparticles was determined. Under the influence of the electromagnetic field, iron oxide nanoparticles reduced the viability of the cancer cell lines ie., 44% after 5 minutes, 31% and 29% after 10 minutes of exposure.