Author:
Suriyage M P,Asanka P V K,Cooray T M G C S P,Liyanage D L F M,Pushpakumara R A N I,Hendavitharana D K,Fernando W W A T I,Sampath W H P,Amarasinghe Y W R
Abstract
Abstract
This paper proposes a novel microfluidic system for a lab on a chip device which includes three major systems: a microchannel, micromixer and a droplet generator. The novel system proposes electroosmotic fluid flow control combining droplet generation and immunocapturing based CTC separation. ANSYS Fluent is used to optimize the fluid flow parameters, droplet size and justify the mixing capability of the micromixer. COMSOL Multiphysics simulations justify the integration of the electroosmotic fluid flow control for precise generation of droplets and optimization of dimensional parameters of microchannels, followed by a fabrication method for the microfluidic system.
Reference18 articles.
1. Deaths: Leading Causes for 2016;Heron;National Vital Statistics Reports,2018
2. Deaths: Leading Causes for 2017;Heron;National Vital Statistics Reports,2019
3. Blood based cancer biomarkers in liquid biopsy: A promising non-invasive alternative to tissue biopsy;Marrugo-Ramírez;International Journal of Molecular Science,2018
4. Enrichment and single-cell analysis of circulating tumor cells;Khajvand;Chem. Sci,2017
5. Isolation of rare circulating tumour cells in cancer patients by microchip technology;Nagrath,2007
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