Toxicity Study of Ananas Comosus and Centella Asiatica as Active Ingredients in Anti-inflammatory Lotion

Abstract

Abstract Inflammation, a common disease faced by people, could lead to chronic inflammatory diseases, and worst, cancer. As a result, many inflammatory patients use nonsteroidal anti-inflammatory drugs (NSAIDs) as to relieve their inflammation, which are available in the market. However, these medicines do not cure the disease but relieve it temporarily, and the patients are exposed to their dangerous long-term effects. Since Malaysia is rich with fruits and herbs that are rich in therapeutic properties, more natural remedies from the local fruits and herbs should be discovered. Based on the previous research done, the combination of Ananas comosus and Centella asiatica could have the potential in relieving inflammation. Therefore, this preliminary research was aimed in determining the toxicity in combining the two main active ingredients using in vitro MTT assay against HaCat Cell lines. The findings proved that at the highest concentration (10000 μg/ml), no cytotoxic effect has been recorded. The findings from this research would encourage more natural remedies to be offered to the inflammation patients, who eventually could avoid themselves from depending solely on the harmful medicines.