Synthesis, Characterization and antibacterial Study of some Complexes Derivatives from1,3,4– Thiadiazole Schiff base

Abstract

Abstract The present study included preparing a new ligand from the thiadiazole derivatives from react between 1,2,5-dihydrazine, 1,3,4-thiadiazol with 4-Dimethyl amino benzaldehyde with a ratio of (1:2) to preparing the ligand (L1) Transition ions complexes (Co+3, Cu+2) were prepared with ligand (L1), the ligand and its complexes were characterized using the elemental analysis (C.H.N.S), Infrared spectrum (FTIR), proton nuclear magnetic resonance spectrum (1H-NMR), Mass spectroscopy, magnetic sensitivity, and molar conductivity, the practical results were exactly in line with the molecular formula and structural formulas for the compounds. The program (Hyper Chem) was used to draw ligands and their complexes and to show the distribution of electron density. The results obtained from the study of magnetic sensitivity and molar conductivity of the prepared ligand complexes confirmed that the geometry shape of [L1CoCl3] is an octahedral complex, while [L1CuCl2] is a square planner complex. The results of molar conductivity also confirmed that the prepared cobalt complex is electrolytic, while the [L1CuCl2] complex is non-electrolytic. The biological activity of the prepared ligand and its complexes were tested against two types of bacteria Staphylococcus aureus and Escherichia Coli in comparison with the standard inhibitor (Ciprofloxacin), the obtained results confirmed the biological activity of the prepared ligand was more than the standard inhibitor (Cipro) against Escherichia coli also the complexes (A1, A2) showed higher biological activity than the standard inhibitor (Cipro) against Escherichia coli (Gram-negative), the ligand and its prepared complexes don’t show biological activity against Staphylococcus aureus(Gram-positive).