Study of New Derivatives of 1,3,4-Thiadiazole and Its Complexes with chromium ion (Cr+3)

Abstract

Abstract The present study included preparing a new ligand from the thiadiazole derivative 2,5-dihydrazineyl-1,3,4-thiadiazol with 4-Dimethyl amino benzyaldehyde with a ratio of (1:2) to preparing the ligand (L1) Transition ion complexe (Cr3+) were prepared with ligand (L1) and ligand and its complexe were diagnosed using the elemental analysis (C.H.N.S), Infrared spectrum (FTIR), Proton nuclear magnetic resonance spectrum (1H-NMR), Mass spectroscopy, magnetic sensitivity and molar conductivity, the practical results were exactly in line with the molecular formula and structural formulas for the compounds.The results obtained from the study of magnetic sensitivity and molar conductivity of the prepared ligand complexe confirmed that the geometry shape of [L1CrCl2]Cl is an octahedral complex . The results of molar conductivity also confirmed that the prepared Chromium complexes is electrolytic . The biological efficacy of the prepared ligand and its complexity were tested against two type of bacteria Staphylococcus aureus and Escherichia Coli in comparison with the standard inhibitor (Ciprofloxacin) , the obtained results confirmed the biological efficacy of the prepared ligand above that of the standard inhibitor (Cipro) , against of the bacteria Escherichia coli, also the complexe (X1) showed higher biological efficacy than standard inhibitor (Cipro) against Escherichia coli (Gram negative), the ligand and its prepared complexe don’t showed biological activity against Staphylococcus aureus .