Nanoencapsulation of ethylvanillin using Electrohydrodynamic technology

Abstract

Abstract An electrohydrodynamic method for preparation of ethylvanillin-loaded polymer-lipid-based nanoparticles. Various parameters of electrohydrodynamic are optimized for generating ethylvanillin-loaded nanoparticles by controllable electrohydrodynamic parameters. Ethylvanillin-loaded polymer-lipid-based nanoparticles with mean diameters of around 64-90nm with encapsulation efficiency in the range 67-71% are generated with all the flow rate from 10 to 25μl/min, the stearic acid-ethylcellulose-ethylvanillin concentration ratio of 4:1:1.6 wt%, and ethylvanillin content of 0.16%. The size of the ethylvanillin-loaded polymer-lipid-based nanoparticles production is examined using scanning electron microscopy.