Creation and analysis of hybrid nanocomposites based on dioxidine and nanoparticles of bioactive metals embedded in cryostructurated gelatin matrices

Abstract

Abstract This paper is devoted to the creation of hybrid nanocomposites based on the antibacterial drug dioxidine and bioactive metals - silver and copper. The obtained materials were analyzed using the methods of NMR, UV and IR spectroscopy, low-temperature adsorption of argon, SEM and TEM. It is shown that they are silver nanoparticles with a size of 2-30 nm or copper nanoparticles with a size of 10-40 nm, incorporated into dioxidine particles with a size of 50-350 nm. The obtained drug nanocomposites were embedded into wide-porous biopolymer cryostructurated gelatin-based matrices. The possibility of the release of drug components from a biopolymer carrier and manifestation of its antibacterial activity has been shown. At the same time, hybrid nanocomposites based on metals and antibacterial drugs showed increased activity to suppress the growth of microbial cells of Escherichia coli 52, Staphylococcus aureus 144, Mycobacterium cyaneum 98, then their components separately.