Synthesis and characterization of non-invasively traceable poly(ether urethane)s for biomedical applications

Abstract

Abstract The ease of real-time visibility of biomedical implants and minimally invasive medical devices is indispensable in radiological imaging to avoid complications and assess therapeutic success. Herein, we prepared a series of polyurethane elastomers with inherent radiopacity, enabling them to be imaged under fluoroscopy. Through an appropriate selection of less toxic intermediates such as 1,6-Diisocyanatohexane (HDI), poly (tetramethylene glycol) (PTMG), and a chain extender, iodinated hydroquinone bis(2-hydroxyethyl) ether (IBHE), new radiopaque polyether urethanes (RPUs) containing about 10.8 to 20.6% iodine contents were synthesized. RPUs were characterized for the physicochemical, thermomechanical and radiopacifying properties. It was observed that the concentration of IBHE had a profound impact on the radiopacity of polyurethanes. RPUs exhibited similar or better radiopacity than an aluminum wedge of equivalent thickness. In-vivo imaging revealed that the RPUs were easily distinguishable from the surrounding tissues. Irrespective of iodine content, all the RPUs were cytocompatible, indicating the suitability of these materials for medical and allied applications.