Abstract
Abstract
In this study, poly(2-hydroxyethyl methacrylate) [p(HEMA)] based hydrogels responsive to the pH, temperature and magnetic field were synthesized. The surface properties of p(HEMA) were improved by designing the stimuli-responsive hydrogels made of MAGA, NIPAAm and methacrylate-decorated magnetite nanoparticles as a function of pH-, thermo- and magnetic responsive cell culture surfaces. These materials were then modified an abundant extracellular matrix component, type I collagen, which has been considered as a biorecognition element to increase the applicability of hydrogels to cell viability. Based on results from scanning electron microscopy (SEM) and thermal gravimetric analysis (TGA), stimuli-responsive hydrogel demonstrated improved non-porous structures and thermal stability with a high degree of cross-linking. Mechanical analyses of the hydrogels also showed that stimuli-responsive hydrogels are more elastomeric due to the polymeric chains and heterogeneous amorphous segments compared to plain hydrogels. Furthermore, surface modification of hydrogels with collagen provided better biocompatibility, which was confirmed with L929 fibroblast cell adhesion. Produced stimuli-responsive hydrogels modulated cellular viability by changing pH and magnetic field.
Funder
Türkiye Bilimsel ve Teknolojik Arastirma Kurumu
Reference33 articles.
1. Hydrogels in biology and medicine: from molecular principles to bionanotechnology;Peppas;Adv. Mater.,2006
2. Radiation formation of hydrogels for biomedical application;Rosiak,2002
3. New hydrogels based on substituted anhydride modified collagen and 2-hydroxyethyl methacrylate;Pamfil;Synthesis and characterization. Industrial & Engineering Chemistry Research,2014
4. 2-hydroxyethyl methacrylate (HEMA): chemical properties and applications in biomedical fields;Montheard;Journal of Macromolecular Science, Part C: Polymer Reviews,1992
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献