Abstract
Abstract
Self-assembling peptides, offering favorable biocompatibility, high stability, and easy incorporation of various functionalities, have demonstrated enormous potential for the precise design of next-generation nanodrugs for non-invasive tumor therapy. Peptide-based supramolecular photodynamic therapy (PDT) has shown great promise as an emerging modality for cancer treatment, achieving substantially-enhanced photosensitizer delivery selectivity and treatment efficacy, based on peptide biological activity and self-assembly potential. Although considerable research has been conducted toward fabricating self-assembling peptide-based smart nanodrugs for PDT, few studies have investigated cellular biophysical responses as indicators of tumor function and metabolic state. Here, via atomic force microscopy (AFM)-based morphological and mechanical measurements, including optical microscopy and scanning electron microscopy, we observed, for the first time, variation in membrane stiffness of human liver (HepG2) cancer cells treated with self-assembling peptides serving as a PDT nanodrug. This biophysical information will help to establish a comprehensive understanding of the anticancer effect of peptide-based smart nanodrugs, and highlight the exceptional ability of AFM in determining cell-surface properties.
Funder
Liaoning Provincial Natural Science Foundation
National Natural Science Foundation of China
Subject
Biomedical Engineering,Biomaterials,Bioengineering
Reference53 articles.
1. Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment;Portillo-Lara;Lab Chip,2016
2. Clinical perspectives of single-cell RNA sequencing;Kim,2021
3. The aging lung: physiology, disease, and immunity;Schneider;Cell,2021
4. Pancreatic cancer: a review of clinical diagnosis, epidemiology, treatment and outcomes;McGuigan;World J. Gastroenterol.,2018
5. A review of cancer immunotherapy: from the past, to the present, to the future;Esfahani;Curr. Oncol.,2020
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献