Abstract
Abstract
The recent advancements in messenger ribonucleic acid (mRNA) vaccine development have vastly enhanced their use as alternatives to conventional vaccines in the prevention of various infectious diseases and treatment of several types of cancers. This is mainly due to their remarkable ability to stimulate specific immune responses with minimal clinical side effects. This review gives a detailed overview of mRNA vaccines currently in use or at various stages of development, the recent advancements in mRNA vaccine development, and the challenges encountered in their development. Future perspectives on this technology are also discussed.
Funder
National Research Foundation South Africa
Durban University of Technology
Subject
Biomedical Engineering,Biomaterials,Bioengineering
Reference223 articles.
1. mRNA vaccine: a potential therapeutic strategy;Wang;Mol. Cancer,2021
2. The promise of mRNA vaccines: a biotech and industrial perspective;Jackson;npj Vaccines,2020
3. The dawn of mRNA vaccines: the COVID-19 case;Verbeke;J. Control. Release,2021
4. Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design;Rice;bioRxiv Preprint,2020
5. COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection;Chi;J. Biomed. Sci.,2022
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