Extracellular matrix as a driver for intratumoral heterogeneity

Author:

Pally Dharma,Goutham Shyamili,Bhat RamrayORCID

Abstract

Abstract The architecture of an organ is built through interactions between its native cells and its connective tissue consisting of stromal cells and the extracellular matrix (ECM). Upon transformation through tumorigenesis, such interactions are disrupted and replaced by a new set of intercommunications between malignantly transformed parenchyma, an altered stromal cell population, and a remodeled ECM. In this perspective, we propose that the intratumoral heterogeneity of cancer cell phenotypes is an emergent property of such reciprocal intercommunications, both biochemical and mechanical-physical, which engender and amplify the diversity of cell behavioral traits. An attempt to assimilate such findings within a framework of phenotypic plasticity furthers our understanding of cancer progression.

Funder

The Wellcome Trust DBT India Alliance

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

IOP Publishing

Subject

Cell Biology,Molecular Biology,Structural Biology,Biophysics

Reference101 articles.

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