The Analysis of Nanomaterials in Nanoparticle Protein Corona Enabled Tests for Early Detection of Cancers

Abstract

Abstract Cancer is the major worldwide cause of thickness and death, leading to the early diagnosis of cancers being the focus of current medicine. According to the World Cancer Research Fund International and Practice Update statistics, the ten-year survival rate of lung cancer is 7%, pancreatic cancer 2.2%. The average ten-year actuarial breast cancer-specific survival rate for all women age groups is 14.1%. The results in an urgent need for early detection of the three cancers to maximize patients’ survival rates. Protein-corona based tests are currently high-profile due to their performance on early diagnosis. When placed in human plasma, the protein patterns will be altered by specific pathologies, causing different protein corona compositions from healthy individuals., Early detection of cancers can be accurately realized through that. This study aims to provide a pathway for future research on nanoparticle-protein-corona-based tests and early diagnosis of lung cancer, pancreatic ductal adenocarcinoma, and breast cancer. This study is conducted by summarizing the currently existing developments and analyzing the performances and the limitations of types of nanomaterials used in the tests. The evidence of effective detection of early-stage cancers by protein-corona enabled tests can attain future research insights.