Evaluation of E-selectin rs 5367 C/T Polymorphism in Iraqi Diabetic Foot patients

Abstract

Abstract Diabetic foot is inflammation disease, including inflammation factors; such as ESelectin. The study aimed to evaluate E-selectin gene SNP rs 5367 C/T polymorphisms with other factors in the Iraqi diabetic foot patients. The study was conducted on 100 Iraqi individual, 50 patients with diabetic foot and 50 as control group. 10ml of blood samples were taken to measured biochemical and genetic variations. The results showed significantly increasing in all biochemical parameter in patient compare to control group except HDL. As results shown no significant differences in the genotype distribution (TT, TC and CC) and allele frequency between the Diabetic foot patients and control groups. Additionally, the genotype TT recorded the highly ratio for patients and healthy individual (60-72%) which may consider the common genotype at Iraqi studied population. In conclusion, both homozygous genotype showed preventive fraction according odds ratio (0.58, 0.93), while CT genotype according odds ratio (1.39) consider as etiological fraction, but not related significantly with disease because all data still in agreement with Hardy-Weinberg so that research wok need more studied to improve a relationship between present locus with disease. Even that according to allele analysis T allele may preventive, while C allele could be etiological for disease.