Relation of angiography to hematological, hormonal and some biochemical variables in coronary artery bypass graft patients

Abstract

Abstract The present study was designed to investigate the relation between severity of atherosclerosis via angiography and alteration of some important biochemical, hormonal and hematological variables in patients underwent Coronary Artery Bypass Graft (CABG) surgery. Eighty adult patients underwent coronary angiography were included in this study, and a standardized case-control study of acute myocardial infarction was established through taking 20 healthy individuals. Diagnostic coronary angiography was performed by a team of expert cardiologists. The patients were grouped according the number of major epicardial coronary arteries into one vessel disease (1VD), two vessels disease (2VD) or three vessels disease (3VD). The evaluation of biochemical tests were performed. The results of association of measurements with the severity of disease showed the priority of cholesterol and its related indexes (especially LDL) rather than TG indicating the severity of atherosclerosis. While, blood glucose and HbA1c were not apparently related to the degree of atherosclerosis. Significant reduction of T3 hormone and platelets and elevation in MPV were recorded in patients suffering from three vessels occlusion. This finding suggested strong association between severity of atherosclerosis and LDL, MPV and T3 in CABG patients.