Study of some clinico-pathological parameters of Thalassemia patients in AL-Zahraa hospital

Abstract

Abstract Thalassemia: is a genetic disorder caused by a defect in production of one or more globin chains of hemoglobin (Hb).Thalassemia is classified into two major groups, namely, α-thalassemia and β-thalassemia according to the particular type of globin chain affected. Various complications caused by this disease including, progressive liver failure and abnormal kidney function.one hundred samples of thalassemia were analyzed at AL-Zahraa hospital education in AL-Najaf province. The patients are aged (10-30) years. The results are compared with control group (50) persons. This study included some of the clinic-pathological and hematological parameters such as some liver enzymes, ferritin, complete blood count, blood film, also age and blood group. The results were (50%) male and (50%) female patients while the control group are (25%) male and (25%) female. Most Patients were (64%) in the age of (10 -15 years), followed by (26%) in the age group of (16 -20 years) and only (5%) in age (21-25 years), also (5%) for age (26 -30 years). Most frequent blood group in this study was O+ is (30%) followed by B+ group (27%) and the other blood groups A+, AB+, A-, O-, AB-, B- were (25%), (11%), (3%), (2%), (1%), (1%) respectively. Levels of Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase and ferritin, in addition to, platelets and White Blood Cells count are higher than normal while Hemoglobin, Hematocrit and Red Blood Cells are decreased. Peripheral blood film of thalassemia patients showing microcytic and hypochromic anemia, in addition to, nucleated Red Blood Cell and large number of target cells. This study demonstrates that thalassemia patients have difference in liver function, serum content ferritin and hematological characteristics in comparison with control group.