Effect of Lactuca serriola on β-Cell dysfunction and Glucose Tolerance induced by High Sucrose fed in Albino Rats

Abstract

Abstract Herbal remedy has been used as efficacious choice for treating type 2 diabetes mellitus in last two decades. The aim of current study is to investigate the hypoglycemic action of Lactuca serriola on chronic hyperglycemia model in male rats. The experiment included four groups and five rates were applied for each group. All rates (except control group) treated with 60% sucrose in diet for 8 weeks. The first group was considered as high sucrose feed (HSF) or model, whiles the second and third groups where administrated with 200 and 500 mg/Kg BW. of Lactuca serriola by gastric gavage respectively. Hyperglycemia was assessed by evaluating fasting blood sugar, serum insulin, HbA1c, oral glucose tolerance test, HOMA-IR and HOMA-B. Moreover, lipid profiles were also measured. The results indicated that induction of chronic hyperglycemia model for 8 weeks led to β-cell dysfunction as HOMA-B significantly (P<0.05) decreased, while both doses of Lactuca serriola restored β -cell function and insulin secretion. Furthermore, Lactuca serriola improved glucose tolerance significantly via measuring the total area under the curve. This finding suggested that Lactuca serriola could be applied as a therapy for chronic hyperglycemia.