Study of the effect of the phenolic extract of the Urtica dioica the level of Des-gamma-prothrombin after treatment with carbon tetrachloride

Abstract

Abstract The present study was conducted on 90 males of Wistar rat weightings (190-300 g), aged (15-17) weeks, at the animal house faculty of science / university of Kufa during the period from December 2016 to July 2017. This study included some physiological to evaluate the protective role of phenolic extract of Urtica dioica leaves (250 and 500 mg/kg ) against hepatotoxicity induced by carbon tetrachloride. The animals experimetal are divided into 22 groups (n=5 rats per each group) for duration of two and three months. The results showed a significant increase (P⩽0.05) in serum levels of biomarker proteins (Des gamma carboxy prothrombin) in carbon tetrachloride groups as compared with the control group. A significant decrease (P⩽0.05) in the serum levels of biomarker proteins (Des gamma carboxy prothrombin) in groups treated with phenolic extract of Urtica dioica as compared with carbon tetrachloride group. The present study concluded that phenolic extract of Urtica dioica leaves had a protective effect on hepatotoxicity in carbon tetrachloride induced group.