Assessment of the Role of Oxidative Stress and Circulating Biochemical markers in Childhood Leukemia

Abstract

Abstract Acute lymphoblastic leukemia (ALL) constitutes a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. The aim of the study was to assess the oxidative status through measurement of antioxidants levels in patients with ALL and deduce any differences in their concentrations from normal values. The study was included 60 children with acute lymphoid leukemia diagnosed by blood film and bone marrow examination and 30 healthy subjects taken as healthy for the initial laboratory tests. Oxidative stress, blood antioxidants status, and liver enzymes profiles were measured in all groups. Our results showed that Antioxidants levels and Hb were significant decreased (P⩽0.05) in ALL patients. In contrast MDA, liver enzymes, leukocytes and Lymphocytes count were significant increase (P⩽0.05) in ALL patients compared to healthy control subjects. Boys predominance was evident, the fraction of patients living in urban areas was more than those of rural regions. Also, the results from statistical analysis revealed that there was a strong correlation between ABO blood groups and leukemia. The present study concludes that free radicals have been concerned in the pathogenesis of leukemia in childhood, the mechanism of increased MDA is that may be due to lymphocyte cells are source superoxide and other oxygen metabolites which lead to lipid peroxidation.