Synthesis, characterization and safety evaluation of raw materials for cyclodextrin fullerene derivatives

Abstract

To further improved the water solubility of fullerene, a new cyclodextrin and fullerene derivative was synthesized in this paper. NMR, elemental analysis, spectral analysis, tunnel scanning electron microscopy and X powder diffraction were used to characterize the material. Spectral analysis showed that the assembly had a wide acromion at 343nm and a large tail band absorption in the range of 350-600nm, indicating the presence of C60. From the STM images, it can be inferred that the weak interaction between the cyclodextrin cavity and the fullerene tail-to-tail form a regular linear arrangement. X-ray shows that there have many characteristic diffraction peak of 11, such as 2θ=11.52° (d=7.68Å), 2θ=14.62° (d=6.05Å), 2θ=25.5° (d=3.49 Å), 2θ=29.62° (d=3.01Å), 2θ=31.68° (d=2.82 Å), which proved that the cyclodextrin and fullerenes formed supramolecular polymers Through chemical safety tests, the results showed that there were no risk substances, pollutants, prohibited substances and restricted substances in the samples which could affect the safety of cosmetics. Phototoxicity, eye irritation/corrosiveness, skin irritation and cytotoxicity were not detected by toxicological safety test. This study provides technical data support for the use of new cyclodextrin and fullerene derivatives as cosmetic raw materials.