Rapid Pressure Hemostatic Drug Delivery and Microsystem Design Based on Battlefield Trauma

Abstract

Abstract The battlefield rapid pressure hemostatic microsystem maximizes hemostasis efficiency. Battlefield wound has the characteristics of rapid blood loss and irregular surface, which needs to be treated in a very short time. The existing rapid hemostasis method has poor efficiency and no sterilization and disinfection effect. Therefore, we reported a wound pressure hemostatic microsystem based on gas generated by rapid chemical reaction. Before the device is used, the two chemicals in the device are isolated. During hemostasis, the flexible device is applied to the wound surface, and the two chemicals in the device are mixed and chemically reacted. And the large amount of gas generated by the reaction causes the balloon in the device to expand and exert lateral and longitudinal pressure on the surface of the wound, so that the wound quickly closed. At the same time, the drug storage unit in the device is under pressure to release the drug to the wound surface. In addition, the chemical reaction of the device has an endothermic effect, which can rapidly cool the wound surface. The lateral and longitudinal pressures of the flexible microsystem in the process of hemostasis were analyzed by numerical simulation. In the experiment, the maximum longitudinal pressure reached 270mmHg, meeting the requirements of surface wound hemostasis.