Theoretical Investigation of Base Pairs-Dependent Electron Transport in DNA System

Abstract

Abstract DNA molecules contain high density genetic information that make them beside their self-assembly and self-recognition properties very remarkable topics for many scientific majors, such as medicine, biology and nanotechnology. The mechanism of electron mobility through DNA is important to study DNA-based molecular electronics in nano-bioelectronics. In this study, the influence of number of base pairs on transmission probability, conductance and current for a DNA system has been investigated by using a tight-binding model. Two DNA sequences, (G/C) and (A/T), was studied using the steady state formalism. One active region of DNA molecules assumed to be represented by a fishbone model. The behavior of transmission spectrum (T) was discussed for both DNA sequences as a function of the number of base pairs (N). In addition, a nonlinear behavior of the current (I) was found by studying I-N curves. Further, the resistance-dependent of number of base pairs is also discussed to describe the resistance behavior and values for both DNA sequences. It demonstrates that the resistance-dependent of number of base pairs represented by nonlinear dependent with small different in its values, and the two DNA sequences gives different R-N curve characteristics.