Vascular Cooling Effect on Temperature Distribution for Hollow Microspheres in Magnetic Induction Hyperthermia: Numerical simulation and analysis

Abstract

Abstract Magnetic Induction hyperthermia is a type of treatment that uses electromagnetic energy to form high temperature area in tumour and kill tumour cells. Magnetic agents can generate heat to increase the temperature. However, researches have shown that the tumour is adjacent to complex vessel systems. Vascular cooling may have great impact on temperature distribution in tumour. Therefore, pre-temperature simulation including vascular cooling effect must be considered to help the clinicians decide the treatment plan. Our previous work has used numerical methods to simulate temperature distribution of avascular model. In this work, we use numerical methods, containing FDM, FVM, BADI and DADI, to simulate the vascular agar model. After comparing the simulation results and vitro heat results, BADI has the smallest error. What’s more, limited by vitro experimental conditions, many vascular parameters cannot be changed in vitro experiments. So we use BADI to simulate the temperature distribution under different conditions containing blood flow rates, vessel diameters and vessel locations. Simulation results show that the blood flow rates and vessel diameters have less impact compared to vessel locations and the blood flow rates affects the least.