The Effect of Plectranthus amboinicus Lour Spreng Ethanolic Extract on Relative Organ, Body Weights Changes, and Hematology Profile in Wistar Rats Treated with 7,12Dimethylbenz(a)anthracene

Abstract

Abstract This study aims to examine the protective properties of ethanol extract Plectranthus amboinicus (EEP) leaves on body weight gain, the relative weight of liver, kidney, lung, spleen, thymus and haematological profile of rats induced by 7,12Dimethylbenz(a)anthracene (DMBA). Used 25 female rats, divided into five groups namely NC (given Carboxymethyl cellulose (CMC) 1%), PC (given DMBA 20 mg/kg body weight), T1, T2, and T3 were each given DMBA 20 mg/kg body weight once every four days for 32 days and EEP 175, 350, and 700 mg/kg body weight given every day from day 33 to 59. Both the DMBA and EEP are given orally using a gastric gavage. On day 60, rats were killed by neck dislocation, bood collected in EDTA tubes for hematological analysis, rats are dissected to obtain liver, kidney, lung, thymus, and spleen organs. Data were analyzed with one way Analisys of varians (ANOVA). The results of this study indicate that EEP in T1, T2 and T3 treatments has no effect on weight loss compared to PC. There was no effect of EEP on the relative weight of the liver, kidneys, spleen, thymus and lungs. EEP increased the number of erythrocytes, leukocytes and platelets in rats that had DMBA