Synthesis and evaluation of anti-microbial of some new Biotin carrying sugar moieties

Abstract

Abstract The current research involves preparing biotin sugar derivatives and evaluating their vital activity against some types of microbial, through a set of interactions, where the biotin was initially converted into an ester derivative according to the Fischer method. Then the ester derivative 2 was treated with aqueous hydrazine to prepare the derivative 3. After that, the derivative 3 was condensed with a number of monosaccharides using the Schiff-Base reaction. The prepared compounds were spectrophotometrically characterized via modern methods. Results of the biological tests showed that the derivatives 4-8 possess antibacterial vital activity as well as anti-fungi.