Study of the effect of Ultraviolet UV-induced oxidative stress in male white rats (Rattus rattus)

Abstract

Abstract The present study was designed to investigate some of the physiological effects in the blood of white male rats exposed to oxidative stress induced by hydrogen peroxide in drinking water at a concentration of 0.5% for a period of 50 days and to compare it with the group exposed to ultraviolet rays at a rate of 6 watts per candle for a period of 50 days First:- The results showed a significant increase (P≤0.05)in the group of rats exposed to radiation in the group of ultraviolet rays (18 watts) UV3 and hydrogen peroxide both when compared with the control group. In radical Peroxy nitrite level and in total white blood cell count and for both Ly % and GR%. The results also showed a significant increase (P≤0.05) in the level of glucose. Second:- There was a significant decrease at a significant level (P≤0.05)in the level of glutathione in the group of rats exposed to UV3 radiation and the hydrogen peroxide group alike when compared with the control group, with a significant decrease at a significant level of (P≤0.05)in the activity of the enzyme glutathione. Glutathione peroxidase and a significant decrease (P≤0.05)in the volume of packed blood cells, the hemoglobin value, the red blood cell count, and the platelet value, with a significant decrease of MO..% Third:- The occurrence of signs of blurred vision in the eyes of the ultraviolet rays group with a strength (3 candles) in addition to the darkening of the tail in a clear and striking way and the lack of movement and activity compared to the hydrogen peroxide group and the rays group, the strength of one candle.