Homogeneous Etherification Modification of Chitosan and Preparation of High-Strength Hydrogel

Abstract

Abstract At present, the ocean as a treasure house of human development resources has attracted widespread attention. Chitin is the most abundant biomass resource in the ocean, and it is also a natural macromolecule second only to cellulose in nature. Its deacetylated product, chitosan, is not only easy to modify physically and chemically, but can be processed into various forms and has excellent properties. Biocompatibility, biodegradability, antibacterial, tissue adhesion and other biological activities. Derivatization reactions are often used to improve the properties of chitosan and give it new structures and functions. In this paper, a series of chitosan ether derivatives were synthesized using alkali/urea aqueous solution as the solvent and homogeneous etherification reaction medium of chitosan, and their structures and properties were characterized. Then, chitosan and quaternized chitosan are dissolved in the acrylic acid monomer aqueous solution, and the chitosan/polyacrylic acid and quaternized high-strength polyelectrolyte composite hydrogel (PEC) are obtained by in-situ polymerization. Finally, the above-mentioned composite hydrogel is treated with Ag+ to obtain the ultra-high strength of the dual interaction of static electricity and coordination bonds, and at the same time a physical cross-linked hydrogel (DPC) with anti-fatigue. The chitosan-based hydrogel with excellent mechanical properties has good application prospects in articular cartilage, wound dressings, bionic stents and the like.